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Can You Take Steroids and Antibiotics Together?.Prednisone (Oral Route) Precautions - Mayo Clinic |
Azithromycin (Oral Route) Precautions - Mayo Clinic - Can You Take Steroids and Antibiotics at the Same Time?
Prednisone and azithromycin. Can You Take Steroids and Antibiotics Together?
Prednisone and azithromycin. The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease
Question I had COVID 6 days of moderate symptoms and was prescribed azithromycin, prednisone, famotidine, and fexofenadine, for allergies. Asked by Lane On Aug 13, Published Aug 16, Last updated Aug 16, Answer Thanks so much for reaching out to us and I hope that you are feeling better! You specifically mentioned azithromycin and prednisone, so I do want to focus on that part. Azithromycin With Prednisone I certainly understand your concern here with taking prednisone.
Additionally, several studies have noted that individuals taking corticosteroids consistently, at high doses to treat certain inflammatory conditions such as rheumatoid arthritis, Crohn's, and ulcerative colitis are more at risk for certain infections due to the immunosuppression prednisone causes, namely: Common viral infections e.
Staphylococcus aureus Common fungal infections Candida species Having said all this, the dose of prednisone you are taking and how long you are taking it is highly relevant. Several studies have published results showing preliminary positive benefits with short-term use of the combination: Current evidence suggests that oral corticosteroids as an adjunctive therapy to oral antibiotics are effective for short-term relief of symptoms in acute sinusitis The point here is that, yes, there are concerns with taking a corticosteroid and how it can suppress the immune system, which increases the risk of infection.
Final Words Thanks for your question and please feel free to reach back out in the future! Was this article helpful? About the Pharmacist Dr. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur.
Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:. Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance for unwanted effects.
Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid. Measure the concentrated liquid with the special oral dropper that comes with the package.
If you use this medicine for a long time, do not suddenly stop using it without checking first with your doctor. You may need to slowly decrease your dose before stopping it completely. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine.
Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Keep from freezing. To be safe, avoid drinking while taking oral steroids or at the very least, limit your intake. Every drug carries a risk of side effects, and steroids and antibiotics are no different.
But in the case of these two drugs, the gastrointestinal side effects can be worse when combined. For example, common side effects of antibiotics are nausea, diarrhea, and upset stomach. Corticosteroids can also cause an upset stomach and cramping , as they irritate the stomach lining. So in short, combining antibiotics and steroids may increase the risk of stomach issues.
This is meant to speed up your healing. Some research has suggested that the two medications work better together than either one alone in treating certain infections. For example, a recent review found that corticosteroids and antibiotics were more effective together in treating bacterial meningitis. Research on mice has also shown that taking steroids and antibiotics together improved recovery time for those with pneumonia. Steroids, Antibiotics, and Meningitis: Plos One.
Prednisone Uses and Interactions: MedlinePlus. Diabetes mellitus. Peptic ulcer disease or history of upper GI bleeding. History of inadequately treated tuberculosis or evidence of tuberculosis in the chest radiography.
Schizoaffective disorder, anxiety or depression treated with antipsychiatric drugs, at present or in the past. Treatment with any investigational drug in any clinical trial within 30 days prior to administration of study medication. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials. More Information. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Cat-scratch Disease Bartonella Infections. Drug: prednison and azithromycin Drug: prednison, azithromycin Drug: prednison, Azenil. Phase 4. Study Type :.
In our latest question and answer, our pharmacist discusses whether or not prednisone can safely be taken with azithromycin. I had COVID 6 days of moderate symptoms and was prescribed azithromycin, prednisone, famotidine, and fexofenadine, for allergies. Can I take all these together? Also, is it better to wait and start prednisone after the Z-Pack since affects some antibiotics?
Don't want to decrease the effect of antibiotics. Answered by Dr. All the drugs you listed in your question azithromycin, prednisone, famotidine, and fexofenadine are considered safe to take together as there is no reported interaction between them. I certainly understand your concern here with taking prednisone. Prednisone is the most commonly prescribed corticosteroid, and corticosteroids, as a class of drugs, are associated with immunosuppressionwhich is why you've probably heard not to take them with antibiotics since you are treating an infection with those.
Additionally, several studies have noted that individuals taking corticosteroids consistently, at high doses to treat certain inflammatory conditions such as rheumatoid arthritis, Crohn's, and ulcerative colitis are more at risk for certain infections due to the immunosuppression prednisone causes, namely:.
Having said all this, the dose of prednisone you are taking and how long you are taking it is highly relevant. Although taking prednisone at any dose and duration can increase the risk of infection, generally, those who take high doses, consistently, are most at risk what a 'high dose' of prednisone is varies by source, but is generally around 40mg or more per day.
Combining an antibiotic with prednisone for short-term treatment of a condition is really a question of if the positives outweigh the risks.
Azithromycin and prednisone are very commonly prescribed together for the short-term treatment of conditions like sinusitis and bronchitis since the benefit of therapy generally outweighs the risk of complications from the combination. In fact, one of the most commonly prescribed combinations of medications used for the short-term treatment of sinus infections is a Medrol Dose Pack which contains methylprednisolone, a similar steroid to prednisone and a Z-Pak azithromycin.
Several studies have published results showing preliminary positive benefits with short-term use of the combination:. The point here is that, yes, there are concerns with taking a corticosteroid and how it can suppress the immune system, which increases the risk of infection. However, for many individuals, a short-term course, at a relatively low dose of a steroid, is considered safe, with the benefits outweighing the risk. It is more commonly those that are taking steroids on a daily basis, or at high doses or both that we are more concerned about.
So, overall, there is no specific interaction between azithromycin and prednisone, and the drugs don't interfere with one another. It's the conflict between immune suppression and treating an active infection that is the concern. As everyone's medical situation is different, I recommend talking to your doctor about what makes the most sense for you.
Brian has been practicing pharmacy for over 11 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Feel free to send him an email at Hello HelloPharmacist.
You can also connect with Dr. Brian Staiger on LinkedIn. I'm in a little bit of pain and want to take something for it. I'm always wary of medicine so prefer An abdominal ultra Facebook Email Twitter Copy Link. Question I had COVID 6 days of moderate symptoms and was prescribed azithromycin, prednisone, famotidine, and fexofenadine, for allergies.
Asked by Lane On Aug 13, Published Aug 16, Last updated Aug 16, Answer Thanks so much for reaching out to us and I hope that you are feeling better!
You specifically mentioned azithromycin and prednisone, so I do want to focus on that part. Azithromycin With Prednisone I certainly understand your concern here with taking prednisone. Additionally, several studies have noted that individuals taking corticosteroids consistently, at high doses to treat certain inflammatory conditions such as rheumatoid arthritis, Crohn's, and ulcerative colitis are more at risk for certain infections due to the immunosuppression prednisone causes, namely: Common viral infections e.
Staphylococcus aureus Common fungal infections Candida species Having said all this, the dose of prednisone you are taking and how long you are taking it is highly relevant.
Several studies have published results showing preliminary positive benefits with short-term use of the combination: Current evidence suggests that oral corticosteroids as an adjunctive therapy to oral antibiotics are effective for short-term relief of symptoms in acute sinusitis The point here is that, yes, there are concerns with taking a corticosteroid and how it can suppress the immune system, which increases the risk of infection.
Final Words Thanks for your question and please feel free to reach back out in the future! Was this article helpful? About the Pharmacist Dr. Brian Staiger, PharmD Dr. Still Confused? Ask the pharmacist a question here! Recent Questions. Nov 17, We'll never share your email with anyone else. Submit Close.
The purpose of this study is to evaluate the efficacy of corticosteroids in addition to azithromycin in CSD. The study hypothesis is that corticosteroids will. Prednisone, a corticosteroid, can suppress the immune system and. The purpose of this study is to evaluate the efficacy of corticosteroids in addition to azithromycin in CSD. The study hypothesis is that corticosteroids will. Dear Dr. Roach: In late spring of , I had a sinus infection and was prescribed both an antibiotic and prednisone. Pirfenidone and azithromycin added to prednisolone may have led to clinical and Corticosteroids have anti-inflammatory action and are effective in the. Although taking prednisone at any dose and duration can increase the risk of infection, generally, those who take high doses, consistently, are most at risk what a 'high dose' of prednisone is varies by source, but is generally around 40mg or more per day. There are no known interactions between alcohol and steroids such as prednisone but drinking large amounts of alcohol may increase your side effects, including an upset stomach. Prednisone is a corticosteroid cortisone-like medicine or steroid. These side effects may go away during treatment as your body adjusts to the medicine. More Information.Study record managers: refer to the Data Element Definitions if submitting registration or results information. Bartonella henselae is the etiologic agent of cat scratch disease CSD. In most CSD cases resolution occurs in 2 to 3 months although a prolonged course often occurs. Data on the efficacy of antibiotic therapy in CSD is limited. Azithromycin has been shown to have a small favorable effect in a small comparative study and is commonly prescribed for CSD, however its overall effect is not satisfactory.
Corticosteroids may be effective in the treatment of CSD for the following reasons:. The total score will consist of the arithmetical summation of the 5 parameters. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
We're building a better ClinicalTrials. Check it out and tell us what you think! Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information. Search for terms. Save this study.
Warning You have reached the maximum number of saved studies The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
Listing a study does not mean it has been evaluated by the U. Federal Government. Read our disclaimer for details. Recruitment status was: Not yet recruiting First Posted : November 10, Last Update Posted : November 11, View this study on Beta.
Study Description. Corticosteroids may be effective in the treatment of CSD for the following reasons: Many experts believe that host response is involved in the pathogenesis of CSD and is responsible for the clinical manifestations rather than the direct effect of B.
The absence of viable organisms in affected lymph nodes in the presence of positive PCR for B. Corticosteroids have been anecdotally reported to have been administered to patients with CSD, apparently with some success.
The purpose of this study is to evaluate the efficacy of corticosteroids in addition to azithromycin in CSD. The study hypothesis is that corticosteroids will improve out come. Patients will be under followed up for 3 months. Major outcome measures will include duration of symptoms and signs, with particular emphasis on affected lymph node size and duration using a specific scoring system lymphadenitis score, LS. LS will be used to evaluate lymphadenitis at each follow-up visit.
The historical control group will be consisted of age, sex, and clinical manifestations-matched CSD patients who were treated with azithromycin without corticosteroids. Drug Information available for: Azithromycin Azithromycin dihydrate Azithromycin monohydrate. FDA Resources. Arms and Interventions. Intervention Details: Drug: prednison and azithromycin Patients with typical cat-scratch disease will be treated with a 5-day course of prednison and azithromycin. Outcome Measures. Eligibility Criteria.
Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Ability and willingness to comply with the protocol. Male and female patients aged years at the time of signing informed consent. Patients with clinical manifestations consistent with early typical cat scratch disease lymphadenitis before spontaneous improvement has been recorded and before development of suppuration.
Known history of allergy, hypersensitivity, or any serious reaction to azithromycin, other macrolides or corticosteroids. Patients for whom azithromycin or corticosteroids is contra-indicated.
Current treatment with systemic corticosteroids. Patients with typical late cat scratch disease who has demonstrated constant improvement in the clinical manifestations of the involved lymph node. Atypical cat scratch disease e. Endocarditis due to Bartonella sp.. Diabetes mellitus. Peptic ulcer disease or history of upper GI bleeding. History of inadequately treated tuberculosis or evidence of tuberculosis in the chest radiography. Schizoaffective disorder, anxiety or depression treated with antipsychiatric drugs, at present or in the past.
Treatment with any investigational drug in any clinical trial within 30 days prior to administration of study medication. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials. More Information. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services.
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Cat-scratch Disease Bartonella Infections. Drug: prednison and azithromycin Drug: prednison, azithromycin Drug: prednison, Azenil.
Phase 4. Study Type :. Interventional Clinical Trial. Estimated Enrollment :. Study Start Date :. Estimated Primary Completion Date :. November 10, Key Record Dates.
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